Single-cell analysis reveals different age-related somatic mutation profiles between stem and differentiated cells in human liver
Kristina Brazhnik, Shixiang Sun, Omar Alani, Milan M. Kinkhabwala, Allan W. Wolkoff, Alexander Y. Maslov, Xiao Dong, Jan Vijg
The paper shows that somatic mutation frequencies increase with age in human liver hepatocytes but are lower in liver stem cells and organoids.
Science Advances · Jan 31, 2020Peer-reviewedGenomics