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Evolutionary Biology· 1

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Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

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Erik VolziD· 1 shared Fabrícia Ferreira do NascimentoiD· 1 shared Kieran O. DrakeiD· 1 shared Vinícius Bonetti FranceschiiD· 1 shared

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Erik VolzORCID

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Evolutionary BiologyJournal of The Royal Society InterfacePeer-reviewedSep 9, 2026

Untangling the effects of within-host and between-host natural selection in viruses with applications to evolution of HIV-1 co-receptor usage

Kieran O. Drake, Vinícius Bonetti Franceschi, Fabrícia Ferreira do Nascimento…·on behalf of the PANGEA Consortium

This paper develops a method to estimate multi-level selection coefficients for pathogens, applying it to HIV-1 co-receptor usage and finding a strong trade-off between within-host and between-host fitness.

DOI 10.1098/rsif.2025.1012

humanDNA methylation

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