Author

Ophelia Dominguez

University of Chicago

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Genetics· 1

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Research Focus:benchmarking· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Andy Dahl· 1 shared Christa CaggianoiD· 1 shared Eimear E. KennyiD· 1 shared Manuela CostantinoiD· 1 shared Renée FonsecaiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperGenetics

Andy Dahl

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1 paper

Recent·Most cited

Locus-specific gene-context interactions improve polygenic prediction

Renée Fonseca, Christa Caggiano, Manuela Costantino, Ophelia Dominguez, Eimear E. Kenny, Andy Dahl

This paper introduces PGSC, a polygenic score framework that incorporates locus-specific gene-context interactions, showing improved prediction across multiple traits and ancestries.

bioRxiv · Aug 28, 2026 · PreprintGenetics