Author

Renée Fonseca

University of ChicagoORCID 0000-0002-9839-6984Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:GWAS summary statistics· 2 Research Focus:polygenic risk· 2 Approach:benchmark study· 1 Research Focus:GWAS / association mapping· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Manuela CostantinoiD· 2 shared Andy Dahl· 1 shared Andy W. DahliD· 1 shared Anjaparavanda P. NareniD· 1 shared Anoushka Menon· 1 shared Arjun BiddandaiD· 1 shared Chinnappa Dilip Kodira· 1 shared Christa CaggianoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetics

Manuela CostantinoORCID

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3 papers

Recent·Most cited

Locus-specific gene-context interactions improve polygenic prediction

Renée Fonseca, Christa Caggiano, Manuela Costantino, Ophelia Dominguez, Eimear E. Kenny, Andy Dahl

This paper introduces PGSC, a polygenic score framework that incorporates locus-specific gene-context interactions, showing improved prediction across multiple traits and ancestries.

bioRxiv · Aug 28, 2026 · PreprintGenetics

Choice of phenotype scale is critical in biobank-based GxE tests

Manuela Costantino, Renée Fonseca, Zhengtong Liu, Zhenhong Huang, Sriram Sankararaman, Iain Mathieson, Andy W. Dahl

The paper shows that phenotype scale choice affects GxE signals in biobank data, with log scaling revealing meaningful effects and explaining a significant portion of PGSxSex interactions.

bioRxiv · Jan 21, 2026 · PreprintGenetics

Distinct positions of genetic and oral histories: Perspectives from India

Arjun Biddanda, Esha Bandyopadhyay, Constanza de la Fuente Castro, David Witonsky, Jose A. Urban Aragon, Nagarjuna Pasupuleti, Hannah M. Moots, Renée Fonseca, Suzanne Freilich, Jovan Stanisavic, Tabitha Willis, Anoushka Menon, Mohammed Shafiul Mustak, Chinnappa Dilip Kodira, Anjaparavanda P. Naren, , Maanasa Raghavan

The paper compares genetic and oral histories of four Indian populations, finding genetic similarity to other Indian groups but no evidence of additional non-local genetic sources.

Human Genetics and Genomics Advances · May 7, 2024Peer-reviewedGenetics