Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome
P. B. Finn, D. Bhimsaria, A. Ali, A. Eguchi, A. Z. Ansari, P. B. Dervan
The paper identifies genome-wide DNA-binding sites of hairpin pyrrole-imidazole polyamides using COSMIC-seq, showing that single-position substitutions alter binding profiles across the human genome.
bioRxiv · Aug 13, 2020Biochemistry