Structural analysis of the OC43 coronavirus 2'-O-RNA methyltransferase
P. Dostalik, P. Krafcikova, J. Silhan, E. Boura
The paper reports the crystal structure of the OC43 coronavirus 2'-O-RNA methyltransferase complexed with sinefungin, revealing conserved SAM binding and structural differences that suggest antiviral target potential.
bioRxiv · Mar 16, 2021Biophysics