Author

P. E. Bourne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Z. Zhao· 2 shared L. Xie· 1 shared

Activity by Year

2016-2019 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBiochemistry

Z. Zhao

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2 papers

Recent·Most cited

Revealing acquired resistance mechanisms of kinase-targeted drugs using an on-the-fly, function-site interaction fingerprint approach

Z. Zhao, P. E. Bourne

This study uses an on-the-fly Fs-IFP approach to analyze drug resistance mechanisms of ALK inhibitors, revealing how mutations affect binding and domain flexibility.

bioRxiv · Nov 13, 2019Biochemistry

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome

Z. Zhao, L. Xie, P. E. Bourne

This paper studies the binding mechanism of MEK type-III inhibitors to inform the design of new allosteric kinase inhibitors across the human kinome.

bioRxiv · Sep 22, 2016Pharmacology & Toxicology