Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils
P. Huettemann, P. Mahadevan, J. Lempart, E. Tse, B. Dehury, B. F. Edwards, D. R. Southworth, B. R. Sahoo, U. Jakob
This study identifies polyphosphate as the 'mystery density' in α-synuclein fibrils by showing it binds to lysine residues, affecting fibril formation and toxicity.
bioRxiv · May 1, 2024 · PreprintBiophysics