Author

U. Jakob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 2 Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Lempart· 3 shared E. Tse· 2 shared K. Ulrich· 2 shared P. Huettemann· 2 shared A. Dhabaria· 1 shared A. Franz· 1 shared A. Sutter· 1 shared B. Dehury· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

J. Lempart

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A dynamic redox switch turns TRC40 into a chaperone protecting human cells against ATP-depleting, oxidative stress

B. Dempsey, R. Dubrall, O. Chan, K. J. Lapacz, J. Riemer, U. Jakob, K. Ulrich

This study shows TRC40 switches from an ATP-dependent targeting factor to an ATP-independent chaperone under oxidative stress, preventing protein aggregation and supporting proteostasis.

bioRxiv · Jul 10, 2024 · PreprintCell Biology

Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils

P. Huettemann, P. Mahadevan, J. Lempart, E. Tse, B. Dehury, B. F. Edwards, D. R. Southworth, B. R. Sahoo, U. Jakob

This study identifies polyphosphate as the 'mystery density' in α-synuclein fibrils by showing it binds to lysine residues, affecting fibril formation and toxicity.

bioRxiv · May 1, 2024 · PreprintBiophysics

Polyphosphate Functions In Vivo as Iron Chelator and Fenton Inhibitor

U. Jakob, F. Beaufay, E. K. Quarles, A. Franz, O. Katamanin, W. Y. Wholey

The paper shows polyphosphate prevents iron-induced oxidative stress by chelating iron and inhibiting the Fenton reaction in bacteria.

bioRxiv · Apr 14, 2020Microbiology

Mycobacterium tuberculosis Rv0991c is a redox-regulated molecular chaperone

S. H. Becker, K. Ulrich, A. Dhabaria, B. Ueberheide, W. N. Beavers, E. P. Skaar, L. M. Iyer, L. Aravind, U. Jakob, K. H. Darwin

This paper identifies Rv0991c in M. tuberculosis as a redox-regulated molecular chaperone essential for virulence, functioning similarly to Hsp33 in E. coli.

bioRxiv · Mar 5, 2020Microbiology

Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity

J. Lempart, E. Tse, J. A. Lauer, M. I. Ivanova, A. Sutter, N. Yoo, P. Huettemann, D. Southworth, U. Jakob

This study investigates how polyphosphate (polyP) affects α-synuclein fibril formation and cytotoxicity, finding that polyP alters fibril morphology and reduces membrane interaction, suggesting potential therapeutic applications.

bioRxiv · Jul 16, 2019Cell Biology

Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding

S. P. Wickramasinghe, J. Lempart, H. E. Merens, J. Murphy, U. Jakob, E. Rhoades

This study shows polyphosphate initiates tau aggregation by altering its conformation and enabling noncovalent cross-linking.

bioRxiv · Mar 25, 2019Biophysics