Suppression of sost/sclerostin and dickkopf-1 promote intervertebral disc structure in mice
T. M. Kroon, P. Niziolek, D. Edwards, E. L. Clinkenbeard, A. G. Robling, N. Holguin
This study shows that suppressing sclerostin or dkk1 promotes intervertebral disc structure by enhancing Wnt signaling, but sclerostin also reduces cellular stress pathways.
bioRxiv · Jul 1, 2021 · PreprintBioengineering