Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43, drive ribonucleoprotein condensate transport dysfunction and suppress local translation
D. Wijegunawardana, S. S. Vishal, N. Venkatesh, P. P. Gopal
This study shows that Ataxin-2 polyglutamine expansions sequester TDP-43, disrupt RNP condensate transport, and suppress local translation in neurons.
bioRxiv · Jan 30, 2023 · PreprintCell Biology