Crystal Structure of Histone Deacetylase 6 Complexed with (R)-Lipoic Acid, an Essential Cofactor in Central Carbon Metabolism
P. R. Watson, J. G. Stollmaier, D. W. Christianson
This paper reports the crystal structure of HDAC6 complexed with (R)-dihydrolipoic acid and shows its redox-regulated interaction with the enzyme's active site.
bioRxiv · Aug 8, 2023Biochemistry