The unfolded protein response links tumor aneuploidy to local immune dysregulation
S. Xian, S. T. Searles, P. Sahani, T. C. Weller, K. Jepsen, H. Carter, M. Zanetti
This study links tumor aneuploidy to local immune dysregulation through the unfolded protein response (UPR), showing increased UPR activity and reduced cytotoxicity in high aneuploidy tumors.
bioRxiv · Nov 10, 2020Cancer Biology