M. Zanetti

Structure selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern

This study shows that structure-selected RBM immunogens induce polyclonal memory responses that neutralize SARS-CoV-2 variants of concern.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans

The paper investigates how MHC-II constraints affect the generation of neutralizing antibodies against the SARS-CoV-2 spike RBM, finding poor peptide binding and potential cross-reactivity with microbial peptides.

The unfolded protein response links tumor aneuploidy to local immune dysregulation

This study links tumor aneuploidy to local immune dysregulation through the unfolded protein response (UPR), showing increased UPR activity and reduced cytotoxicity in high aneuploidy tumors.

IRE1? regulates macrophage polarization, PD-L1 expression and tumor survival

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.