Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks
T. Amimeur, J. M. Shaver, R. R. Ketchem, J. A. Taylor, R. H. Clark, J. Smith, D. Van Citters, C. C. Siska, P. Smidt, M. Sprague, B. A. Kerwin, D. Pettit
This paper uses a GAN to generate diverse human antibody libraries with controlled properties, validated through phage display and biophysical evaluation.
bioRxiv · Apr 12, 2020 · PreprintImmunology