Unbiased in vivo exploration of nuclear bodies-enhanced sumoylation reveals that PML orchestrates embryonic stem cell fate
S. Tessier, O. Ferhi, M.-C. Geoffroy, R. Gonzalez-Prieto, A. Canat, S. Quentin, M. Pla, M. Niwa-Kawakita, P. Bercier, D. Rerolle, P. Therizols, E. Fabre, A. C. O. Vertegaal, H. de The, V. Lallemand-Breitenbach
This study shows PML regulates mESC fate via SUMO2-conjugation of key regulators, revealing its role in stress responses and pluripotency.
bioRxiv · Jun 29, 2021Cell Biology