Interconversion of unexpected thiol states affects stability, structure and dynamics in engineered antibody for site-specific conjugation
C. T. Orozco, M. J. Edgeworth, P. W. A. Devine, A. R. Hines, O. Cornwell, X. Wang, J. J. Phillips, P. Ravn, S. E. Jackson, N. J. Bond
The paper investigates how an unexpected disulfide bridge in an engineered antibody affects its stability, structure, and dynamics through mass spectrometry and biophysical techniques.
bioRxiv · Sep 28, 2020 · PreprintBiophysics