Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
R. O. Formiga, F. C. Amaral, C. F. Souza, D. A. G. B. Mendes, C. W. S. Wanderley, C. B. Lorenzini, A. A. Santos, J. Antonia, L. F. Faria, C. C. Natale, N. M. Paula, P. C. S. Silva, F. R. Fonseca, L. Aires, N. Heck, , F. Spiller
This paper shows neuraminidase inhibitors reduce neutrophil overactivation in sepsis and COVID-19 by inhibiting sialic acid release and ROS production.
bioRxiv · Nov 12, 2020 · PreprintImmunology