Mechanistic Insights into the Structural Asymmetry of the LanFEG Transporter NisFEG in Lantibiotic Immunity
Pablo A. Cea, Julia Gottstein, Stephan Schott-Verdugo, Christian Mammen, Sander H. J. Smits, Holger Gohlke
This study constructs a full-atom model of the NisFEG transporter in the ATP-bound state, revealing structural asymmetry and interaction mechanisms critical for nisin extrusion and bacterial immunity.
bioRxiv · Oct 9, 2025 · PreprintBiophysics