Sander H. J. Smits

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

This study shows that the catalytic activity of Ubp3, a yeast deubiquitinase, is independent of its interaction partner Bre5, challenging the current model of Bre5-dependent activation.

This study investigates the conformational dynamics of the membrane-anchored foldase LipH and shows how it recognizes, folds, and releases its client lipase LipA.

The paper identifies and structures MpTACO1, a dual-targeted protein in plants, showing its role in enhancing translation of mitochondrial and plastid-encoded proteins.

The paper introduces ATPLyzer, a ratiometric biosensor for monitoring ATP dynamics, showing its utility in E. coli and demonstrating growth-phase and carbon-supply-dependent ATP changes.

The paper introduces CoBiSe, a computational method for biosensor design, and demonstrates its application in creating IronSenseR, a biosensor for ferrous iron with high specificity and sensitivity.

The paper investigates how siderophore exploitation and spatial structure influence microbial community dynamics in iron competition.

This study identifies the sux gene cluster in Xanthomonas oryzae pv. oryzae as essential for sucrose uptake, which supports bacterial growth, motility, biofilm formation, and virulence in rice.

This study investigates how acylation of the RTX toxin MbxA enhances membrane disruption by interacting with cholesterol, showing acylation promotes pore formation but not initial membrane binding.

The paper presents the first complete structural model of the HlyA T1SS using cryo-EM and SAXS, revealing CLD domain dynamics and toxin binding mechanisms.

This study constructs a full-atom model of the NisFEG transporter in the ATP-bound state, revealing structural asymmetry and interaction mechanisms critical for nisin extrusion and bacterial immunity.

The paper determines the structure of crTPpart2 from two chromatophore-targeted proteins, revealing a fold similar to γ-glutamyl-cyclotransferase and suggesting its role in protein import.

The paper identifies Tue1, a fungal effector from Thecaphora thlaspeos, which interacts with JAZ10 to modulate jasmonate signaling in plants, suggesting a conserved structural effector family in fungal pathogens.

This study identifies Jps1 as a key protein facilitating unconventional secretion in Ustilago maydis by interacting with phosphoinositides, revealing its structural and functional roles in Cts1 export.

This study identifies structural features of the MLLE domain in Rrm4 and reveals its role in recognizing short linear motifs for mRNA transport during endosomal trafficking.

The paper determines the crystal structure of Bep1, revealing a novel FIC-OB-BAS(BID) domain arrangement and its role in T4SS translocation.