Dose dependent impact of global Cc2d1a reduction on cognitive, social, and metabolic phenotypes
Abigail T. Heller, Aniket Bhattacharya, Pallavi Routray, Shanzeh S Rauf, Vinitha Uppalapati, Emma Suzuki, Susanna Weiss, M. Chiara Manzini
This study investigates the dose-dependent effects of CC2D1A reduction in mice, finding that ~90% loss leads to ASD/ID-like behaviors in males and metabolic changes, while ~80% loss does not.
bioRxiv · Oct 10, 2026 · PreprintNeuroscience