Spatial Single-Cell Proteomics Reveals Molecular Trajectories Of Tangle-Bearing Neurons In Alzheimer's Disease
Martha S. Foiani, Mathieu Bourdenx, Kraller Lukas, Raja Nirujogi, Yiu Angela, Davies Hannah, Patel Saisha, Luiza-Simona Damoc, Ludovico Mitchener, Zane Jaunmuktane, Fabian Coscia, Karen Duff
The paper uses spatial single-cell proteomics to analyze tangle-bearing neurons in Alzheimer's disease, revealing a continuum of proteomic changes associated with tau pathology.
bioRxiv · Apr 29, 2026 · PreprintNeuroscience