Karen Duff

This paper develops a scalable human neuronal model of 4R tauopathy with endogenous seed-competent tau for drug discovery.

This paper introduces coppaFISH 3D and CASTalign to enable transcriptomic identification of thousands of in vivo recorded neurons at scale.

The paper uses spatial single-cell proteomics to analyze tangle-bearing neurons in Alzheimer's disease, revealing a continuum of proteomic changes associated with tau pathology.

This study shows that temporal interference stimulation enhances neural progenitor cell maturation in vitro and promotes hippocampal neurogenesis in a mouse Alzheimer's model.

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

The paper identifies tau filaments within extracellular vesicles from Alzheimer's disease patients using mass spectrometry and cryo-electron microscopy.

The paper describes the development of triple MAPT mutation knock-in mice that exhibit early tau pathology and behavioral abnormalities, useful for studying frontotemporal dementia and related tauopathies.

This study uses spatial transcriptomics to identify gene signatures in the human temporal cortex linked to Alzheimer's pathology.

The paper uses MRI and TBM to show that tau pathology spread in a mouse model correlates with brain volume loss but not neuronal loss in specific regions.

This study shows that reducing Aβ-induced hyperactivity in the entorhinal cortex decreases Aβ and tau pathology in a mouse model of Alzheimer's disease.

The paper investigates how APOE4 affects bioenergetic pathways in specific brain regions of aged mice, finding region-specific differences that may contribute to Alzheimer's disease risk.

This study shows that targeting GPCRs to enhance synaptic proteasome activity reduces tau accumulation and cognitive decline in a mouse model of Alzheimer's disease.