Tfam knockdown results in reduction of mtDNA copy number, OXPHOS deficiency and abnormalities in zebrafish embryos
Auke B.C. Otten, Rick Kamps, Patrick J. Lindsey, Mike Gerards, Hélène Pendeville, Marc Müller, Florence H. J. van Tienen, Hubert J.M. Smeets
This study shows that reducing Tfam in zebrafish embryos decreases mtDNA copy numbers, causes OXPHOS deficiency, and leads to developmental abnormalities.
Frontiers in Cell and Developmental Biology · Jun 12, 2020Peer-reviewedDevelopmental Biology