Network analysis links genome-wide phenotypic and transcriptional stress responses in a bacterial pathogen with a large pan-genome.
Paul A. Jensen, Zeyu Zhu, Tim van Opijnen
The paper combines RNA-Seq and Tn-Seq data from S. pneumoniae to analyze stress responses, finding that expression and fitness changes are largely decoupled and occur in distinct subnetworks.
bioRxiv · Aug 26, 2016 · PreprintSystems Biology