Genetic assessments of breast cancer risk that do not account for polygenic background are incomplete and lead to incorrect preventative strategies
George Busby, Paul Craig, Nesrine Yousfi, Saurabh Hebbalkar, Paolo Di Domenico, Giordano Bottà
The paper shows that polygenic risk scores significantly affect the penetrance of rare breast cancer mutations and highlights the importance of including polygenic background in genetic risk assessments.
medRxiv · Aug 13, 2021 · PreprintGenetic & Genomic Medicine