George Busby

This study identifies key considerations for accrediting polygenic risk score testing through stakeholder consultations and proposes checklists for quality assessment.

The paper investigates adaptive admixture at the Duffy locus in Oman, finding evidence of selection for Duffy null alleles linked to reduced P. vivax prevalence.

This paper introduces a cost-effective targeted nanopore sequencing approach for P. falciparum genomic surveillance, validated with mock and field samples.

The paper shows that polygenic risk scores significantly affect the penetrance of rare breast cancer mutations and highlights the importance of including polygenic background in genetic risk assessments.

This study identifies five genome-wide associations with severe malaria risk in 17,000 individuals from Africa, Asia, and Oceania, including a new variant linked to cerebral malaria.

The paper identifies ancestry deviation regions in sub-Saharan African populations to infer recent adaptive gene-flow contributing to traits like lactose persistence and malaria resistance.

The paper identifies a structural variant in GYPA and GYPB genes associated with reduced risk of severe malaria in sub-Saharan African populations.

This study analyzes admixture patterns in 48 African populations, revealing recent gene flow and shared ancestry due to historical migrations and agricultural expansions.