Human Umbilical Cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications
Arjun Saha, Sachit A. Patel, Li Xu, Paula Scotland, Jonathan D. Schwartzman, Anthony J. Filiano, Joanne Kurtzberg, Andrew E. Balber
The paper shows that cord blood monocytes, not adult blood monocytes, protect brain cells from hypoxic-ischemic injury through secreted factors, with CD14+ monocytes being critical.
PLoS ONE · Sep 4, 2019Peer-reviewedNeuroscience