Accelerated Apolipoprotein A-II senile amyloidosis in a PAI-1 (plasminogen activator inhibitor 1) knock-out model
Gilles Roussine Codo, Pauline Duchatelet, Gemma Martinez-Rivas, Alessio Lampis, Karolina Weronika Świderska, Émilie Pinault, Camille Cohen, Magali Colombat, Sébastien Bender, Christophe Sirac
This study shows PAI-1 knockout mice develop systemic AApoA-II amyloidosis at intermediate age, with amyloid deposits in multiple organs and urinary albumin as a biomarker, highlighting potential risks of PAI-1 inhibition in amyloidosis.
bioRxiv · Dec 23, 2025 · PreprintPathology