Systematic evaluation of 24 extraction and library preparation combinations for metagenomic sequencing of SARS-CoV-2 in saliva
Kenin Qian, Varada Abhyankar, Dahlia Keo, Payton Zarceno, Traci L. Toy, Eleazar Eskin, Valerie A. Arboleda
The paper evaluates 24 metagenomic sequencing workflows for SARS-CoV-2 detection in saliva, finding that RNA-Seq library preparation has a greater impact on viral read recovery than extraction methods.
bioRxiv · Apr 20, 2026 · PreprintGenomics