Telomerase RNA regulates the epigenome primed for human lineage commitment
Jie Li, Peng Su, Mingqi Gao, Chang Liu, Niannian Li, Guofeng Feng, Yongqin Yu, Z Q Chen, Guoxing Yin, Xiaoying Ye, Jiangtao Lu, Ziyi Jin, Zhengmao Zhu, Haiying Liu, Hua Wang, L Liu
This study shows TERC regulates chromatin accessibility and epigenomic architecture in hESCs, essential for lineage commitment, independent of telomere length.
bioRxiv · Jul 3, 2026 · PreprintCell Biology