Hua Wang

Telomerase RNA regulates the epigenome primed for human lineage commitment

This study shows TERC regulates chromatin accessibility and epigenomic architecture in hESCs, essential for lineage commitment, independent of telomere length.

Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune Cells

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment

This study shows that a CTCF R567W mutation causes developmental disorders by altering 3D genome structure and neurodevelopmental pathways in mouse and human models.

FOXA2 is essential for maintaining the urea cycle in acute liver failure

This study identifies FOXA2's role in maintaining urea cycle function in acute liver failure by regulating CPS1 transcription and preventing hyperammonemia.

Invigorating human MSCs for transplantation therapy via Nrf2/DKK1 co- stimulation in a mice acute-on-chronic liver failure model

This study shows that co-stimulating Nrf2 and DKK1 in human MSCs improves their therapeutic efficacy in a mouse ACLF model by enhancing anti-inflammatory and regenerative effects.

Mutation rate estimation for 15 autosomal STR loci in a large population from Mainland China

This study estimates mutation rates for 15 autosomal STR loci in a large Chinese population and finds higher paternal mutation rates and correlations with age and geographic location.