6mA demethylase Mi-NMAD-1 modulates nematode development and parasitism through the transcription factor Mi-nhr-118
Dadong Dai, Yucheng Liao, Dexin Bo, Shahid Siddique, Yayi Zhou, Boyan Hu, Shurong Zhang, Yali Zhang, Pengfei Zhu, Donghai Peng, Ming Sun, Jinshui Zheng
This study identifies Mi-NMAD-1 as an essential 6mA demethylase in nematodes, showing its role in development and parasitism through regulation of Mi-nhr-118.
bioRxiv · Dec 19, 2025 · PreprintMolecular Biology