Apolipoprotein E ε4 exacerbates microglia-mediated complement-dependent synapse loss caused by neuronal Tpk deficiency
Pengyue Du, Boru Jin, Zijie Wang, Binqiao Zhao, Shaoming Sang, Chunjiu Zhong
This study shows APOE4 worsens synapse loss in Tpk-deficient mice through microglia-mediated complement pathways, leading to behavioral issues.
bioRxiv · Jan 16, 2025 · PreprintNeuroscience