Shaoming Sang

This study shows APOE4 worsens synapse loss in Tpk-deficient mice through microglia-mediated complement pathways, leading to behavioral issues.

This paper investigates how amyloid-β modulates TPK-1 expression in microglia, showing TPK deficiency contributes to plaque propagation and microglia dysfunction in Alzheimer's disease.

This study shows that TPK deficiency in the brain leads to Alzheimer's pathology in mice and is specific to AD in humans.

This study uses multilayered N-glycoproteomics to show impaired N-glycosylation in Alzheimer's disease mouse models, affecting protein function and neuronal health.