A Pseudotime-Dependent TWAS Framework Identifies Disease Genes along Cell Developmental Paths
Rui Cao, Chunlin Li, Erjia Cui, Logan G. Spector, Andrew R. Raduski, Nathan Anderson, Weihua Guan, Peter Gordon, Cindy Im, Tianzhong Yang
The paper introduces pt-TWAS, a framework that identifies disease genes along cell developmental paths by modeling gene expression as a continuous function of pseudotime, improving resolution over discrete cell-type analyses.
Human Genetics and Genomics Advances · Jun 23, 2026Peer-reviewedGenetic & Genomic Medicine