Author

Peter Wolynes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Davit Potoyan· 2 shared Bin Zhang· 1 shared Elizabeth Komives· 1 shared Weihua Zheng· 1 shared

Activity by Year

2015-2017 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 3 mutual co-author links

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2 shared papersSystems Biology

Davit Potoyan

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3 papers

Recent·Most cited

Stochastic dynamics of genetic broadcasting networks

Davit Potoyan, Peter Wolynes

The paper shows that passive thermodynamics in genetic networks can cause a time-scale crisis, which is resolved by actively regulating transcription factor residence times using molecular stripping, illustrated with NF-κB dynamics.

Physical Review E · Nov 3, 2017Peer-reviewedSystems Biology

Shape Transitions and Chiral Symmetry Breaking in the Energy Landscape of the Mitotic Chromosome

Bin Zhang, Peter Wolynes

The paper derives an energy landscape for mitotic chromosomes that exhibits chiral symmetry breaking and helical twisting, similar to interphase TAD structures.

bioRxiv · Nov 11, 2015Biophysics

Molecular stripping in the NFκB/IκB/DNA genetic regulatory network

Davit Potoyan, Weihua Zheng, Elizabeth Komives, Peter Wolynes

The paper investigates the molecular stripping mechanism in the NFκB/IκB/DNA genetic switch using simulations, showing it operates via an allosteric mechanism and conformational selection.

bioRxiv · Oct 2, 2015Biophysics