Spatiotemporal Atlas of Heart Development Reveals Blood-Flow-Dependent Cellular, Structural, Metabolic, and Spatial Remodeling
Jooyoung Park, Shuofei Sun, Rohit Agarwal, Andreas Stephanou, Mong Lung Steve Poon, Hyun Maeng, Peyton Lancaster, Iwijn De Vlaminck, Jonathan Talbot Butcher
The paper generates a spatiotemporal atlas of heart development using flow perturbations and spatial transcriptomics to study how blood flow affects cellular, structural, and metabolic remodeling.
bioRxiv · Dec 12, 2025 · PreprintDevelopmental Biology