Dynamics and fate of beneficial mutations under lineage contamination by linked deleterious mutations
Sophie Penisson, Tanya Singh, Paul D. Sniegowski, Philip J Gerrish
The paper models the dynamics of beneficial mutations under lineage contamination by linked deleterious mutations, finding that survival probabilities are modified by a correction factor and that there is an optimal deleterious mutation rate for maximizing beneficial mutation production.
bioRxiv · Aug 8, 2016Evolutionary Biology