Saturating hepatic clearance drives elevated cfDNA and fragment shortening in cancer
Thomas W. Rachman, William A. LaFramboise, Phillip H. Gallo, Patricia Petrosko, Daisong Liu, Rahul Kumar, Marija Balić, Steffi Oesterreich, Julia Foldi, Adrian V. Lee, Patrick L Wagner, David L. Bartlett, Russell S. Schwartz, Oana Carja
This study shows that elevated cfDNA and fragment shortening in cancer are due to saturated hepatic clearance, not tumor burden alone.
bioRxiv · Mar 6, 2026 · PreprintCancer Biology