Author

William A. LaFramboise

Allegheny Health NetworkORCID 0000-0002-6024-810XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David L. BartlettiD· 2 shared Russell S. SchwartziD· 2 shared Adrian V. LeeiD· 1 shared Daisong Liu· 1 shared Julia FoldiiD· 1 shared Marija BalićiD· 1 shared Oana CarjaiD· 1 shared Patricia Petrosko· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

David L. BartlettORCID

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2 papers

Recent·Most cited

Saturating hepatic clearance drives elevated cfDNA and fragment shortening in cancer

Thomas W. Rachman, William A. LaFramboise, Phillip H. Gallo, Patricia Petrosko, Daisong Liu, Rahul Kumar, Marija Balić, Steffi Oesterreich, Julia Foldi, Adrian V. Lee, Patrick L Wagner, David L. Bartlett, Russell S. Schwartz, Oana Carja

This study shows that elevated cfDNA and fragment shortening in cancer are due to saturated hepatic clearance, not tumor burden alone.

bioRxiv · Mar 6, 2026 · PreprintCancer Biology

Marker selection strategies for circulating tumor DNA guided by phylogenetic inference

Xuecong Fu, Zhicheng Luo, Yueqian Deng, William A. LaFramboise, David L. Bartlett, Russell S. Schwartz

The paper develops methods to improve marker selection for ctDNA analysis by refining phylogenetic models and quantifying clonal frequencies through optimization.

Bioinformatics · Mar 29, 2025Peer-reviewedBioinformatics