Author

Pilar Gomez-Alcala

Columbia University

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Genomics· 1

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Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Christ LeemansiD· 1 shared Harmen J. BussemakeriD· 1 shared Lucas A. N. MeloiD· 1 shared Richard S. ManniD· 1 shared Shaoxun LiuiD· 1 shared William J. GlassfordiD· 1 shared Xiang‐Jun LuiD· 1 shared

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Christ LeemansORCID

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1 paper

Recent·Most cited

GenomicsNucleic Acids ResearchPeer-reviewedAug 8, 2025

Predicting the DNA binding specificity of transcription factor mutants usingfamily-level biophysically interpretable machine learning

Shaoxun Liu, Pilar Gomez-Alcala, Christ Leemans…·Harmen J. Bussemaker

The paper develops a method to predict how mutations in transcription factors affect their DNA binding specificity using biophysically interpretable machine learning.

6 citations

DNA methylationChIP-seq

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