Astrocytic FKBP5 Regulates Neuroinflammation and Cognitive Outcomes in Excitotoxic Brain Injury
Yu‐Ling Gan, Shang H. Lin, Yu-Ping Kang, Jia-Zhen Zhou, Wei-Hsuan Huang, Ping-Hua Sung, Chia‐Chi Hung, Pei-Chien Hsu, Shu-Yin Chu, Feng‐Shiun Shie, I‐Hui Lee, Chung‐Jiuan Jeng, Yi-Hsuan Lee
This study shows that FKBP51 in astrocytes promotes neuroinflammation and cognitive deficits after excitotoxic brain injury, with reduced inflammation and improved cognition in Fkbp5 knockout mice.
Brain Behavior and Immunity · Jan 13, 2026Peer-reviewedNeuroscience