S4-Multi: enhancing polygenic score prediction in ancestrally diverse populations
John Baierl, Jonathan P. Tyrer, Ping-Hung Lai, Simon A. Gayther, Yi-Wen Hsiao, Michelle R. Jones, Paul D.P. Pharoah, Pei-Chen Peng
S4-Multi improves polygenic score prediction across diverse ancestries by reducing genetic variants while maintaining accuracy in non-European populations.
Human Genetics and Genomics Advances · Nov 27, 2025Peer-reviewedGenetic & Genomic Medicine