Yi-Wen Hsiao

Measuring the accuracy of electronic health record (EHR)-based phenotyping in the All of Us Research Program to optimize statistical power for genetic association testing

The paper evaluates EHR-based phenotyping accuracy in the All of Us Research Program to optimize statistical power for genetic association testing, finding disparities in accuracy across racial groups.

S4-Multi: enhancing polygenic score prediction in ancestrally diverse populations

S4-Multi improves polygenic score prediction across diverse ancestries by reducing genetic variants while maintaining accuracy in non-European populations.

Engineering single-AAV CRISPR-Cas13 RNA base editors for treatment of inherited retinal diseases

This paper develops an RNA base editor using CRISPR-Cas13 and ADAR2DD to correct mutations in inherited retinal diseases, showing up to 60% editing efficiency in vitro and partial rescue in mouse models.

Characterisation of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina

This study characterizes the transcriptomic effects of Cas13bt3 in retinal cells and demonstrates its efficacy in silencing VEGFA mRNA in human retinal organoids and mouse models.

RNASeqR: an R package for automated two-group RNA-Seq analysis workflow

RNASeqR provides an automated RNA-Seq analysis workflow in R, enabling six-step processing and visualization for comparative transcriptomic studies.