In vivo activation of the dia BGC allows consolidation of the biosynthetic pathways of diaporthin, dichlorodiaporthin, diaporthinic acid, and diaporthinol
Isabella Burger, Simon Leonhartsberger, Kathrin Peikert, Lukas Fourtis, Polina Atanasova, Lara T. S. Kramer, Richard Fried, Christian Stanetty, Florian Rudroff, Ruth Birner‐Gruenberger, Robert Ludwig Mach, Astrid Rosa Mach-Aigner, Matthias Schittmayer, Christian Zimmermann
This study activates the dia biosynthetic gene cluster in Trichoderma reesei, identifying diaporthinic acid as the primary metabolite and elucidating the roles of key genes in its biosynthesis.
bioRxiv · Mar 31, 2025 · PreprintBiochemistry