Neuroprotective action of agonists and modulators of A 1 adenosine receptors upon hyperexcitation: mechanism of the antiepileptic activity and role of neuron-glial interaction
Sergei G. Gaidin, Sergei A. Maiorov, Denis P. Laryushkin, Kristina A. Kritskaya, Alexey V. Berezhnov, Valentina N. Mal’tseva, Polina Rhazantseva, Irina A. Gorbunova, Daria A. Shipilovskikh, Yulia O. Sharavyeva, Sergei Alexandrovich Shipilovskikh, Ivan A. Andreev, Nina K Ratmanova, Olga Aleksandrovna Ivanova, Igor V. Trushkov, , Artem Mikhailovich Kosenkov
This study investigates the antiepileptic and neuroprotective effects of A1 adenosine receptor agonists and modulators in various models of hyperexcitation, showing their ability to suppress seizures and improve survival.
bioRxiv · Oct 21, 2025 · PreprintNeuroscience