Prioritizing peptides for targeted mass spectrometry experiments using deep learning
Shreyash Sonthalia, Bo Wen, Pooja Dasgupta, Chris Hsu, Michael J. MacCoss, William Stafford Noble
Bromo, a pairwise transformer, ranks a protein's peptide precursors by expected mass spectrometry response, beating XGBoost, PREGO and PeptideRanger on held-out yeast data, and can be fine-tuned per instrument.
bioRxiv · Aug 31, 2026 · PreprintBioinformatics✦ In-depth digest