A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells
Mugdha V. Joglekar, Subhshri Sahu, Wilson K. M. Wong, Sarang N. Satoor, Charlotte X. Dong, Ryan J. Farr, Michael D. Williams, Prapti Pandya, Gaurang Jhala, Sundy N.Y. Yang, Yi Vee Chew, Nicola A. Hetherington, Dhan Thiruchevlam, Mitnala Sasikala, Guduru Venkat Rao, , Anandwardhan A. Hardikar
The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.
bioRxiv · Mar 2, 2021 · PreprintDevelopmental Biology