Nicola A. Hetherington

Epigenomic and transcriptomic germ-free ageing atlas reveals sterile inflammation as an intrinsic ageing feature

This study presents a single-cell epigenomic and transcriptomic atlas of aged mice under germ-free conditions, revealing sterile inflammation as an intrinsic ageing feature.

snRNA-seq analysis of the moss Physcomitrium patens reveals a conserved cytokinin-ESR module promoting pluripotent stem cell identity

The paper uses snRNA-seq to analyze moss stem cells, identifying a cytokinin-ESR module that promotes pluripotent stem cell identity in the gametophore apical cell.

UniverSC: a flexible cross-platform single-cell data processing pipeline

UniverSC is a single-cell RNA-sequencing processing pipeline that supports UMI-based platforms, enabling consistent integration and comparison across diverse data sources.

A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells

The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.